Cardiac, respiratory and metabolic conditions represent the most prevalent conditions encountered by exercise physiologists. This unit presents current medical and scientific knowledge of cardiac, respiratory and metabolic disorders and diseases. An examination of the aetiology, incidence, epidemiology and pathophysiology of the disease processes, as well as the adaptations that lead management of the disease is a major focus of the unit. Current evidence and guidelines for exercise testing and exercise prescription as related to cardiac respiratory and metabolic disorders will be discussed in detail. Methodological aspects of the clinical assessment will be discussed and applied together with the principles of available exercise prescriptions and other treatment therapies.